GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7789940 | 1 | rs11765693 | chr7:75985373 | UPK3B | chr7:76139745-76157197:+ | -0.24 | -6.3 | 4.43E-10 | Multiple sclerosis |
| BRCA | cis | rs848490 | 1 | rs11765986 | chr7:77357274 | PHTF2 | chr7:77428109-77586818:+ | -0.16 | -4.45 | 9.57E-6 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| BRCA | cis | rs1799922 | 1 | rs11766175 | chr7:128405013 | OPN1SW | chr7:128412545-128415844:- | 0.16 | 3.88 | 0.000109 | Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth) |
| BRCA | cis | rs6951245 | 1 | rs11766526 | chr7:1101433 | ZFAND2A | chr7:1192544-1199855:- | -0.3 | -5.87 | 5.65E-9 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BRCA | cis | rs848490 | 1 | rs11767651 | chr7:77390380 | PHTF2 | chr7:77428109-77586818:+ | -0.16 | -4.63 | 4.17E-6 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| BRCA | cis | rs2066819 | 1 | rs117683816 | chr12:56638267 | COQ10A | chr12:56660642-56664748:+ | -0.29 | -4.09 | 4.65E-5 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs117683816 | chr12:56638267 | RPS26 | chr12:56435686-56438005:+ | -0.29 | -3.69 | 0.000233 | Psoriasis vulgaris |
| BRCA | cis | rs2066819 | 1 | rs117683816 | chr12:56638267 | SLC39A5 | chr12:56623820-56631627:+ | -0.27 | -3.9 | 0.000102 | Psoriasis vulgaris |
| BRCA | cis | rs848490 | 1 | rs11770446 | chr7:77358072 | PHTF2 | chr7:77428109-77586818:+ | -0.16 | -4.43 | 1.04E-5 | Glomerular filtration rate (creatinine);Glomerular filtration rate in non diabetics (creatinine) |
| BRCA | cis | rs6951245 | 1 | rs11770909 | chr7:1086716 | ZFAND2A | chr7:1192544-1199855:- | -0.34 | -6.66 | 4.43E-11 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BRCA | cis | rs801193 | 1 | rs11773829 | chr7:66141074 | TYW1 | chr7:66461817-66704496:+ | -0.15 | -4.01 | 6.39E-5 | Aortic root size |
| BRCA | cis | rs1853207 | 1 | rs117756203 | chr10:96601144 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.42 | 7.28E-8 | Blood metabolite levels |
| BRCA | cis | rs867186 | 1 | rs117802529 | chr20:33786677 | MMP24 | chr20:33814539-33864804:+ | -0.22 | -3.7 | 0.000227 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs867186 | 1 | rs117802529 | chr20:33786677 | PROCR | chr20:33758727-33765164:+ | -0.25 | -4.88 | 1.23E-6 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| BRCA | cis | rs4831760 | 1 | rs11780499 | chr8:15534249 | TUSC3 | chr8:15397730-15621993:+ | -0.18 | -4.23 | 2.57E-5 | Pulmonary function decline |